Equal opportunity CAR T cells

Equal Opportunity.

Design and development of CAR-T cells for cancer therapy

Introduction: Today, treatment with CAR-T cells is accepted as an effective treatment for blood malignancies. CAR-T cells are autologous T cells that are engineered by gene transfer techniques to express a chimeric antigen receptor (CAR). Despite the promising results and the approval of six CAR-T cell products; these products have not yet been approved for solid tumors. In addition, the high c...

Equal opportunity for all.

By sequencing tens of millions of TCRa transcripts from naive mouse CD8 T cells, Genolet et al (2012) show that the TCRa repertoire is at least as diverse as the TCRb repertoire. This overturns a long held view in the field that recombination of the Tcra locus occurs in a co-ordinate sequential bidirectional manner that relies on proximity of Va and Ja gene segments. The observation that rearra...

Tobacco: an equal-opportunity killer?

In their article, Jamrozik et al (see page 258) have explored the mortality hazard associated with smoking by gender and provide evidence that Australian men and women with similar smoking histories (namely, cigarettes smoked per day and time since quit) experience similar rates of death from smoking. Given the limitations of the data in this study, caution should be used in interpreting these ...

Discrimination, Affirmative Action, and Equal Opportunity